SMN 2024 sponsors

Gold (Agilent, Leco, Shimadzu, Waters), Silver (Bronze, Sciex), Bronze (Element, Thermo, Merck, Peak Scientific, Avantor) sponsors with Network and Training sponsors (SULSA and Biomedical AI UKDRI CDT) and Stratocore

Industry Sponsors SMN2022

Gold Sponsors

Silver Sponsors

Bronze Sponsors

Other Sponsors

Award Sponsors

Industry Sponsors SMN2021

Award Sponsors

Metabolomics Society

The Metabolomics Society, of which the Scottish Metabolomics Network is an affiliate, is dedicated to promoting the growth, use and understanding of metabolomics in the life sciences. The Metabolomics Society is an independent, non-profit organization, governed by a board of directors composed of dedicated members of the metabolomics community but ultimately responsive to its members. The Metabolomics Society's vision is to become the premier organization devoted to the development of metabolism-based research. Constituted in 2004, the Metabolomics Society now has more than 1,000 members in more than 40 countries.

Our Mission:

To promote the growth and development of the field of metabolomics internationally,
To provide the opportunity for collaboration and association among the workers in that science and in related sciences and connections between academia, government and industry in the field of metabolomics
To provide opportunities for presentation of research achievements and creation of workshops, and
To promote the publication of meritorious research in the field.

metabolomicssociety.org

Royal Society of Chemistry: Interest Group - Food

@RSC_FoodGroup

The food group aims are to promote the role of chemistry in food and enable transfer and sharing of information and networking between academia and the food industry. This includes analytical, biochemical, chemical, physical, nutritional and toxicological aspects of food and food ingredients and the composition and relationships between structure and functionality throughout the entire food chain in a way to enhance sustainability and food and nutrition security.

www.rsc.org

Gold Sponsors

Shimadzu

Shimadzu Corporation was founded in 1875 and for over 140 years has been at the forefront of industrial and scientific innovation. Shimadzu is the global leader in LC technologies and is the fastest growing mass spectrometry company in the world with solutions for non-targeted and targeted metabolomics and lipidomics workflows.

Shimadzu’s solutions for non-targeted and targeted metabolomics and lipidomics include GCMS(GCMS-TQ8050 NX | SHIMADZU EUROPA) and LC coupled to triple quadrupole (https://www.shimadzu.co.uk/lcms/lcms-8060nx) and Quadrupole Time-of-Flight (https://www.shimadzu.co.uk/lcms-9030 ) platforms. Our instrumentation is a powerful combination of sensitivity, robustness and speed and enables us to do more in a single analysis. Combined with our intuitive data processing software, our solutions are streamlined for metabolomics and lipidomics workflows.

Browse Shimadzu LCMS range here: Liquid Chromatograph-Mass Spectrometry or speak to our UK based metabolomics experts at this meeting or contact us via email: LCMS@shimadzu.co.uk.

www.shimadzu.co.uk

Thermo Fisher Scientific

Go beyond – Harness the power of metabolomics

Biology is complex. To decipher these complexities, metabolomics analysis demands sophisticated analytical technologies and software solutions. We aim to address the whole workflow from sample preparation, sample separation by a range of chromatographic systems and columns, sample analysis by state-of-the-art mass spectrometry and other related techniques and subsequent data processing and analysis.

By collaborating with the scientific community, we’ve developed pioneering solutions driven by Thermo Scientific™ Orbitrap™ mass spectrometers enable broader and deeper analyses into the metabolome. Our industry-leading breadth in chromatographic separations, GC, LC and IC, combined with the technical depth of our systems and consumables, together produce novel, stringent and reproducible results for high impact discoveries whether that be in targeted or untargeted metabolomics, lipidomics or beyond.

Deeper and broader analysis for untargeted metabolomics

Untargeted metabolomics compares the relative abundances of all metabolites in multiple samples, often complex, without prior knowledge. Both the separation techniques and the high resolution accurate mass (HRAM) Orbitrap MS must be highly reproducible, have high sensitivity and be capable of measuring a wide dynamic range of compounds ranging from very hydrophilic to hydrophobic metabolites for comprehensive coverage.

Thermo Scientific Thermo Fisher Scientific has invested heavily in developing metabolomics software that lives up to the high standards set by our leading instrumentation. Our suite of integrated applications is built to take you quickly from data acquisition to interactive analysis and interpretation of results. Thermo Scientific™ Compound Discoverer™ software is the ultimate toolbox for complete analysis of untargeted metabolomics data, Mass Frontier™ takes the challenge out of structural elucidation and TraceFinder™ rapidly detects targeted knowns for QA/QC, profiling, and absolute quantitation.

Targeted profiling and quantitation solutions

Identified biomarkers from either untargeted metabolomics experiments, or hypothesis-driven from the literature, can be verified or validated where usually a limited number of compounds are quantified in a large set of samples.

For highest selectivity and confirmation, HRAM Orbitrap mass spectrometry is the technology of choice for verification of putative biomarkers. Moving through to high-throughput quantitation, SRM analysis on the Thermo Scientific™ TSQ™ triple quadrupole mass spectrometers is the solution of choice.

Comprehensive lipidomics solutions

Lipidomics is a field of metabolomics that has evolved into a class all its own and aims to map and quantify lipid species sets within a cell or tissue to identify biomarkers and elucidate metabolism at the cellular level. Lipid species are diverse and complex, and the development of HRAM Orbitrap MS has risen to the challenge of lipid analysis, offering an unprecedented level of sensitivity, selectivity and precision.

www.thermofisher.com/metabolomics

www.thermofisher.com

Waters

If you are performing research in the Metabolomics arena, Waters Corporation is uniquely placed to provide exclusive tools, to help you gain success in your research. We are keen to understand what drives your research and are open to collaborate, to introduce you to new technologies and innovations, to help advance your science.

Waters have a catalogue of innovative mass spectrometry products that can help you to achieve your metabolomic goals. Amongst these are Ion Mobility (IMS) and Cyclic Ion Mobility (cIMS), which are superb tools to help with the sample complexity, inherent to metabolomic analyses, alongside our unique DESI Imaging capability.

High Resolution MS Technologies

Ion Mobility (IMS)

Provides orthogonal separation power - IMS resolution is sufficient to separate ions not amenable to m/z separation. i.e. isomers, conformers
Provides increased peak capacity - giving significant gains in selectivity (analytical peak capacity) and specificity (confidence in results), when compared to the use of m/z separation alone

Cyclic Ion Mobility (cIMS)

Provides all the benefits of IMS, with ultimate performance and unique analytical capabilities
Scalable mobility resolution, with user defined multi-pass experiments
IMSn acquisition modes, for multiple rounds of fragmentation/mobility separation

SONAR

SONAR provides increased selectivity, compared to a conventional DIA experiment, while collecting data at UPLC compatible speeds
Allows you to qualitatively identify metabolites in complex samples and extract high resolution quantitative information from a single injection

DESI - MS Imaging for Biomedical Research

Molecular visualization and spatial distribution of compounds, provides mechanistic insight
The spatial distribution of molecular species, in a sample, is crucial to gaining key insight into biological, chemical and physiological processes
Mass spectrometry imaging (MSI) with Desorption Electrospray Ionization Mass Spectrometry (DESI) produces label-free, multiplexed and objective measurement of molecular targets from complex surfaces. This direct-from-sample analytical technique provides researchers with the spatially resolved molecular information, needed to quickly and objectively interpret molecular profiles and understand mechanistic insights with confidence

Key features of Waters DESI Imaging

Ambient analysis technique to visualize the spatial localization and distribution of molecules
No sample preparation. Collect molecular information directly from tissue samples
Compatible with current histopathological workflows such as H&E Staining
Measure small molecule drugs, lipids and endogenous metabolites
Integration with METASPACE, SCiLS and Lipostar-MSI software packages

Targeted Omics Method Libraries

Waters Targeted Omics Method Library (TOML) provides instant access to a wide variety of valuable targeted LC-MS/MS methods. Created by some of the world’s best method developers, TOML method packages include an application note, a file containing all the chromatographic and spectrometric settings for the method, and a list of stable-isotope labelled standards. By simply downloading and importing the method files, you can expand the menu of assays provided in your lab, in a matter of hours. TOML is provided free of charge, to further enhance the value of your Waters LC-MS system.

www.waters.com/waters/es_ES/Targeted-Omics/nav.htm?cid=134980821&locale=es_ES

ACQUITY Premier LC and Columns

The ACQUITY Premier System, is the next evolution of the ACQUITY UPLC platform of liquid chromatography systems. Along with the reliability, ruggedness, high quality, and configuration flexibility you expect from the ACQUITY UPLC Series, the ACQUITY Premier System delivers a step change in chromatographic performance, lab efficiency, and risk control.

The ACQUITY Premier System features novel MaxPeak High Performance Surfaces (HPS) technology, which effectively reduces non-specific adsorption losses due to metal interactions, and provides:

Reduced analysis times
Improved peak shapes
Decreased reagent costs
Improved LODs and RSDs
Reliable quantitation
Lower system downtime

The technology is also incorporated in our ACQUITY Premier Columns, which feature MaxPeak High Performance Surfaces, significantly reducing non-specific adsorption losses, due to metal interactions. An example of the analytical benefit of the ACQUITY Premier Columns, is available in the below Application Note, using a zwitterionic-HILIC phase, for the analysis of RNA Nucleotides, Nucleosides and Nucleobases:

www.waters.com/nextgen/en/library/application-notes/2021/improved-separation-of-rna-nucleotides-nucleosides-and-nucleobases-on-atlantis-premier-beh-z-hilic-columns.html

Data Interpretation

When it comes to data interpretation, we have best in class software packages to help take the headache out of feature identification:

Metabolic Profiling & Lipidomic Profiling CCS Libraries

When using IMS acquisition, you can use the CCS of analysed molecules, as an additional uniquely identifying feature
The Waters Metabolic Profiling CCS Library includes more than 900 measurements of collision cross section (CCS) values, and more than 600 MS/MS spectra

Progenesis QI

Progenesis QI is small molecule discovery analysis software; a revolutionary ‘difference engine’
The built-in Metascope search engine enables ID of compounds using mass, RT, fragmentation spectra and CCS
Uses publicly available and in-house databases
The co-detection workflow results in improved matching, peak picking and normalisation, which allows robust uni-variate and multi-variate statistical analysis and false positive correction
Can handle high numbers of highly complex samples

METLIN® MS/MS Library for Progenesis QI

Implementation of the METLIN library directly within Progenesis QI
One of the most comprehensive and widely used metabolite databases, represents the largest MS/MS collection of metabolite data, generated at multiple collision energies, in positive and negative ionization modes
Includes over 240,000 different compounds, with over 13,900 individually analysed, with measured MS/MS, and over 220,000 with in silico MS/MS data

www.waters.com

Agilent

Agilent Technologies Inc. (NYSE: A) is a global leader in life sciences, diagnostics, and applied chemical markets, delivering insight and innovation toward improving the quality of life. Agilent instruments, software, services, solutions, and people provide trusted answers to customers' most challenging questions. The company generated revenue of $5.34 billion in fiscal 2020 and employs 16,400 people worldwide. Information about Agilent is available at www.agilent.com. To receive the latest Agilent news, subscribe to the Agilent Newsroom. Follow Agilent on LinkedIn, Twitter and Facebook.

Bruker

www.bruker.com

Sciex

Metabolomics research not only holds the key to revealing interactions taking place in biological complexes, it is instrumental to discovering new drugs, biomarkers and uncovering disease pathology. SCIEX offers a complementary portfolio of solutions to measure, process, characterise and translate your research into biological knowledge.

Discovery Metabolomics

The SCIEX discovery metabolomics workflow can uncover and identify new compounds that could be putative biomarkers or key elements of important metabolic pathways. With the power of the TripleTOF® system, there's no need to choose between data acquisition methods. With one sample injection, you can process your data to screen for unknown metabolites or focus on only those compounds of interest with a targeted metabolite screening approach.

Unknown Metabolite Screening: When little information exists about a sample, or new information is desired, this data processing approach will allow you to discover all compounds that are different between samples. With XCMSplussoftware you can simultaneously quantify and identify thousands of features across hundreds of samples and search the METLIN database to identify metabolites of interest.
Targeted Metabolite Screening: When you want to extract information for known compounds, this data processing approach enables hypothesis-driven data analysis. Using MasterView™ software, and the Accurate Mass Metabolite Spectral Library you can concentrate on finding and quantifying changes between known compounds, such as all metabolites within a specific biochemical pathway. Then MultiQuant™ software and MarkerView™ software enables rigorous quantitation and statistical analysis of those compounds across hundreds of samples.